Projekt

Imaging of chemical microenvironment of pathogenic biofilms

Udbyder

Vejleder

Sted

København og omegn

Biofilms are much more tolerant to antibiotics than planktonic bacteria due to factors such as physical
protection and slow growth-rates caused by diffusion limitation of metabolic substrates due to high
bacterial- and immune cell activity.

A more detailed understanding of the chemical microenvironment, and thus resource availability, around pathogenic biofilms could lead to faster and easier diagnostics and provide tools for the development of novel treatment strategies.

In this project, the student will work on developing methods for high resolution imaging of chemical species using indicator dyes of e.g. pH and O2 to investigate heterogeneities in chemical landscapes on a microscale to elucidate interactions between chemical microenvironment and growth rates of pathogenic bacteria.

Required qualifications:
The student should be familiar with basic laboratory techniques, such as pipetting and reagent preparation.

In addition, the student should be able to work independently and be intrigued by technical challenges and method development.

Allowed no of students: 1

I samarbejde med

University of Copenhagen

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Kontakt

Virksomhed/organisation

DTU Sundhedsteknologi

Navn

Thomas Sams

Stilling

Sektionsleder for Biomedical Engineering, Lektor, PhD

Mail

tsams@dtu.dk

Vejleder-info

Kandidatuddannelsen i Medicin og Teknologi

Vejleder

Thomas Sams

Type

Kandidatspeciale

OM DTU

DTU er et teknisk eliteuniversitet med international rækkevidde og standard. Vores mission er at udvikle og nyttiggøre naturvidenskab og teknisk videnskab til gavn for samfundet. 10.000 studerende uddanner sig her til fremtiden, og 5.700 medarbejdere har hver dag fokus på uddannelse, forskning, myndighedsrådgivning og innovation, som bidrager til øget vækst og velfærd.

Find os her

Anker Engelunds Vej 1
Bygning 101A
2800 Kgs. Lyngby


45 25 25 25

dtu@dtu.dk

CVR-nr. 30 06 09 46

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