Projekt

MOLECULAR CAUSES OF ALZHEIMER'S DISEASE: FROM PROTEIN TO PATIENT

Udbyder

Vejleder

Sted

København og omegn

What causes Alzheimer's and how do we find a cure? This project aims to pinpoint underlying molecular causes of Alzheimer's Disease by direct coupling of clinical data for patients suffering from genetic forms of the disease with the chemical properties of the protein mutants that these patients carry.

This coupling is a unique technique developed by our research group at DTU which has led to a range of recent breakthroughs in the understanding of the disease in 2015 and 2016 (1,2,3,4).

Alzheimer’s Disease is a devastating neurodegenerative disease and one of the major challenges of this century, with millions of people affected world-wide and prevalence growing steadily (5,6,7).

The specific objectives of this project are 1) to construct a major database of Alzheimer’s Disease including both clinical data (survival times, age of diagnosis/onset) for patients who have inherited Alzheimer's and the associated chemical properties of the corresponding protein variants; 2) show that statistically significant correlations exist between these two types of data; 3) identify the protein properties that correlate with disease. These properties can then be used to develop biomarkers for early-stage diagnosis and in future drug discovery programs directed towards treating this terrible neuro-degenerative disease.

The project involves a range of bioinformatics tools, physical chemistry and computational chemistry techniques and can vary in difficulty from undergraduate and bachelor students, to master student level.

 

(1) Somavarapu, A. K.; Kepp, K. P. The Dynamic Mechanism of Presenilin-1 Function: Sensitive Gate Dynamics and Loop  Unplugging Control Protein Access. Neurobiol. Dis. 2016, 89, 147–156.

(2) Somavarapu, A. K.; Kepp, K. P. Loss of Stability and Hydrophobicity of Presenilin 1 Mutations Causing Alzheimer’s Disease. J. Neurochem. 2016.

(3) Tiwari, M. K.; Kepp, K. P. β-Amyloid Pathogenesis: Chemical Properties versus Cellular Levels. Alzheimer’s Dement. J. Alzheimer's Assoc. 2016, 12 (2), 184–194.

(4) Somavarapu, A. K.; Kepp, K. P. Direct Correlation of Cell Toxicity to Conformational Ensembles of Genetic Abeta Variants. ACS Chem. Neurosci. 2015, 6, 1990–1996.

(5) Goedert, M.; Spillantini, M. G. A Century of Alzheimer’s Disease. Science 2006, 314 (2006), 777–781.

(6) Kepp, K. P. Bioinorganic Chemistry of Alzheimer’s Disease. Chem. Rev. 2012, 112 (10), 5193–5239.

(7) Kepp, K. P. Alzheimer’s Disease due to Loss of Function: A New Synthesis of the Available Data. Prog. Neurobiol. 2016, 143, 36–60.


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Kontakt

Virksomhed/organisation

DTU Kemi

Navn

Kasper Planeta Kepp

Stilling

Professor

Mail

kpj@kemi.dtu.dk

Vejleder-info

Kandidatuddannelsen i Anvendt Kemi

Vejleder

Kasper Planeta Kepp

ECTS-point

5 - 30

Type

Bachelorprojekt, Kandidatspeciale, Specialkursus

OM DTU

DTU er et teknisk eliteuniversitet med international rækkevidde og standard. Vores mission er at udvikle og nyttiggøre naturvidenskab og teknisk videnskab til gavn for samfundet. 10.000 studerende uddanner sig her til fremtiden, og 5.700 medarbejdere har hver dag fokus på uddannelse, forskning, myndighedsrådgivning og innovation, som bidrager til øget vækst og velfærd.

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Anker Engelunds Vej 1
Bygning 101A
2800 Kgs. Lyngby


45 25 25 25

dtu@dtu.dk

CVR-nr. 30 06 09 46

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