Projekt

In vitro electrochemical monitoring of allergic reactions

Udbyder

Vejleder

Sted

København og omegn

The prevalence of allergic diseases is increasing worldwide, especially in low and middle income countries. Allergic diseases comprehend life-threatening anaphylaxis, food allergies, certain forms of asthma, rhinitis, conjunctivitis, eczema, angioedema, urticarial, eosinophilic disorders, drug and insect allergies. The World Allergy Organization estimated that 20-30% of the world population suffered from some form of allergic disease in 2003, with the greatest burden for children and young men. One tenth of the world population suffers for drug allergies and 400 million for rhinitis and about 250 million are allergic to some kind of food. 

Although a lot of research has been conducted to investigate the mechanisms behind allergic reactions there is still a lack of knowledge on several fundamental phenomena related to allergy. Here, we propose the development of an in vitro model which could provide real-time electrochemical monitoring of degranulation of mast cells triggered by allergic reactions. Carbon microelectrodes will be fabricated in the Danchip cleanroom. Mast cells will be cultured on the electrodes and the release of histamine upon mast cell activation will be studied. The long-term vision is to develop a new type of allergy test. The project is conducted as a collaboration between DTU Nanotech and the Allergy Clinic at Gentofte Hospital.
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Kontakt

Virksomhed/organisation

DTU Nanolab

Navn

Stephan Sylvest Keller

Stilling

Lektor

Mail

suke@dtu.dk

Vejleder-info

Bachelor i Medicin og Teknologi

Vejleder

Stephan Sylvest Keller

ECTS-point

25 - 35

Type

Kandidatspeciale

Bachelor i Bioteknologi

Vejleder

Stephan Sylvest Keller

ECTS-point

25 - 35

Type

Kandidatspeciale

Bachelor i Teknisk Biomedicin

Vejleder

Stephan Sylvest Keller

ECTS-point

25 - 35

Type

Kandidatspeciale

Kandidatuddannelsen i Medicin og Teknologi

Vejleder

Stephan Sylvest Keller

ECTS-point

25 - 35

Type

Kandidatspeciale

Kandidatuddannelsen i Bioteknologi

Vejleder

Stephan Sylvest Keller

ECTS-point

25 - 35

Type

Kandidatspeciale

Kandidatuddannelsen i Farmateknologi

Vejleder

Stephan Sylvest Keller

ECTS-point

25 - 35

Type

Kandidatspeciale

OM DTU

DTU er et teknisk eliteuniversitet med international rækkevidde og standard. Vores mission er at udvikle og nyttiggøre naturvidenskab og teknisk videnskab til gavn for samfundet. 10.000 studerende uddanner sig her til fremtiden, og 5.700 medarbejdere har hver dag fokus på uddannelse, forskning, myndighedsrådgivning og innovation, som bidrager til øget vækst og velfærd.

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Anker Engelunds Vej 1
Bygning 101A
2800 Kgs. Lyngby


45 25 25 25

dtu@dtu.dk

CVR-nr. 30 06 09 46

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