Projekt

in vitro analysis of small molecular agonist and antagonist towards an orphan drug target.

Udbyder

Vejleder

Sted

København og omegn

This study is a cross disciplinary project with partners from DTU Food, DTU Bioinformatics and DTU Chemistry as well as collaborators from DTU Vet. Additionally, the project is conducted in collaboration an startup company partner Idun genomics IVS. The project is funded by the DTU PoC Fund.

We have identified a novel drug target for the treatment of inflammatory bowel diseases (IBD).

IBD are autoimmune and chronic diseases involving relapsing inflammation of the gastrointestinal tract (GIT). The two major types of IBD are Crohn’s disease (CD), involving inflammation in any part of the GIT, and ulcerative colitis (UC), where inflammation is limited to the colon. IBD is believed to result from continuous inappropriate inflammation in response to commensal microbes in susceptible individuals, but the etiology and pathogenesis of IBD is poorly understood. Current treatment of IBD includes aminosalicylates, corticosteroids, immune modifiers or anti-tumor necrosis factor (anti-TNF) agents, but a great number of patients are still unresponsive to treatment or become unresponsive over time.

The aim of this project is to investigate novel, proprietary compounds for their effect on a newly identified IBD drug target. You will learn about working with human cell lines and in a mammalian cell lab. The different technics that you will learn are ELISA, cAMP assay, western blotting and qRT-PCR. Additionally, other molecular and cell biological methods will be used. As part of the project, the best candidate molecules will be selected for testing in an in vivo animal model for IBD. We are looking for an ambitious and goal oriented student with a flair for laboratory work that wants to join a cross disciplinary and energetic team.

If you will like to hear more about the team and the project please contact:

 


Mads H. Clausen
Professor
mhc@kemi.dtu.dk
Cell: 20 84 01 31

Claus Heiner Bang-Berthelsen

Senior Scientist

Claban@food.dtu.dk

Cell:29 86 69 00


I samarbejde med

Idun Genomics

Søg i opslag
Kontakt

Virksomhed/organisation

DTU Fødevareinstituttet

Navn

Claus Heiner Bang-Berthelsen

Stilling

Seniorforsker

Mail

claban@food.dtu.dk

Vejleder-info

Kandidatuddannelsen i Bioinformatik og Systembiologi

Vejleder

Claus Heiner Bang-Berthelsen

Medvejledere

Mads Hartvig Clausen

ECTS-point

30 - 60

Type

Kandidatspeciale

Kandidatuddannelsen i Medicin og Teknologi

Vejleder

Claus Heiner Bang-Berthelsen

Medvejledere

Mads Hartvig Clausen

ECTS-point

30 - 60

Type

Kandidatspeciale

Kandidatuddannelsen i Bioteknologi

Vejleder

Claus Heiner Bang-Berthelsen

Medvejledere

Mads Hartvig Clausen

ECTS-point

30 - 60

Type

Kandidatspeciale

Kandidatuddannelsen i Kemisk og Biokemisk Teknologi

Vejleder

Claus Heiner Bang-Berthelsen

Medvejledere

Mads Hartvig Clausen

ECTS-point

30 - 60

Type

Kandidatspeciale

OM DTU

DTU er et teknisk eliteuniversitet med international rækkevidde og standard. Vores mission er at udvikle og nyttiggøre naturvidenskab og teknisk videnskab til gavn for samfundet. 10.000 studerende uddanner sig her til fremtiden, og 5.700 medarbejdere har hver dag fokus på uddannelse, forskning, myndighedsrådgivning og innovation, som bidrager til øget vækst og velfærd.

Find os her

Anker Engelunds Vej 1
Bygning 101A
2800 Kgs. Lyngby


45 25 25 25

dtu@dtu.dk

CVR-nr. 30 06 09 46

Liste over EAN Numre

Job på DTU

Se alle jobs
 

loading..