Projekt

C-reactive protein - An acute phase protein explored as a biomarker

Udbyder

Vejleder

Sted

København og omegn

Background: C-reactive protein (CRP) is a prominent acute phase protein in a number of species including humans. CRP is associated with the acute phase response to tissue damage as an evolutionary ancient innate systemic host defense reaction. The biosynthesis of CRP is triggered by tissue damage resulting in dramatic (>100 fold) increases in serum concentrations following shortly after injury. CRP has five identical subunits each being capable of independently binding one molecule of phosphocholine (see figure). It has innate immune modulating activities which are dependent on the binding of phosphocholine (PC) and on the structural integrity of the pentamer. Project aim: The aim of this project is to investigate modulation of CRP bioactivity by phosphocholine and synthetic phosphocholine derivatives mimicking the biologically relevant phosphocholine structures . Three types of phosphocholine derivatives, simple phosphocholine and phosphocholine with two different spacers will be studied initially (see figure). Subsequently, the binding of multivalent phosphocholine ligands will be investigated using computational methods. The binding affinities calculated using the computational methods will be correlated to binding affinity bioassays (e.g. ELISA) and furthermore correlated with bioassays measuring the subsequent pro- or anti-inflammatory activation of CRP. Departments: The project is a collaboration between DTU Chemistry and DTU Vet.

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Kontakt

Virksomhed/organisation

DTU Kemi

Navn

Günther H.J. Peters

Stilling

Professor

Mail

ghp@kemi.dtu.dk

Vejleder-info

Kandidatuddannelsen i Anvendt Kemi

Vejleder

Günther H.J. Peters

Medvejledere

Ulrik Boas, Peter M. H. Heegaard

Kandidatuddannelsen i Bioinformatik og Systembiologi

Vejleder

Günther H.J. Peters

Medvejledere

Ulrik Boas, Peter M. H. Heegaard

Kandidatuddannelsen i Farmateknologi

Vejleder

Günther H.J. Peters

Medvejledere

Ulrik Boas, Peter M. H. Heegaard

Kandidatuddannelsen i Medicin og Teknologi

Vejleder

Günther H.J. Peters

Medvejledere

Ulrik Boas, Peter M. H. Heegaard

Bachelor i Bioteknologi

Vejleder

Günther H.J. Peters

Medvejledere

Ulrik Boas, Peter M. H. Heegaard

Bachelor i Kemi og Teknologi

Vejleder

Günther H.J. Peters

Medvejledere

Ulrik Boas, Peter M. H. Heegaard

Bachelor i Medicin og Teknologi

Vejleder

Günther H.J. Peters

Medvejledere

Ulrik Boas, Peter M. H. Heegaard

Bachelor i Teknisk Biomedicin

Vejleder

Günther H.J. Peters

Medvejledere

Ulrik Boas, Peter M. H. Heegaard

OM DTU

DTU er et teknisk eliteuniversitet med international rækkevidde og standard. Vores mission er at udvikle og nyttiggøre naturvidenskab og teknisk videnskab til gavn for samfundet. 10.000 studerende uddanner sig her til fremtiden, og 5.700 medarbejdere har hver dag fokus på uddannelse, forskning, myndighedsrådgivning og innovation, som bidrager til øget vækst og velfærd.

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Anker Engelunds Vej 1
Bygning 101A
2800 Kgs. Lyngby


45 25 25 25

dtu@dtu.dk

CVR-nr. 30 06 09 46

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