Projekt

Slug flow µ-reactors for two-liquid phase biocatalysis

Udbyder

Vejleder

Sted

København og omegn

In biocatalytic reaction it is often favorable to have reaction conditions, where two different fluid dynamic phases are in contact with each other. This might for instance be a water-based phase holding the water soluble fractions of reaction components like enzymes, while another phase is insoluble in water and containing the other substrates of the reaction. _x000D_ _x000D_ Very often a so called slug flow reactor is used in minaturized approaches, where the different phases are introduced with help of continious flowrates resulting in a segmented flow of different phases. _x000D_ Comlex flow fields are obtained with intensive secondary flows, resulting in good mixing (see for example Taha and Cui, 2006, CFD modelling of slug flow inside square capillaries, Chemical Engineering Science, 61, 665-675)._x000D_ _x000D_ Using minaturized slug flow reactors for biocatalytic reactions gain more and more importance since it is possible to separate water based active components from substrates dissolved in more aggressive environments, which would inhibit or destroy the acitve sites of the biocatalysts. Furthermore the different phases can also be used to apply liquid liquid extraction from products and to influence in this way the thermodynamic equilibrium._x000D_ _x000D_ The proposed project wil perform a proof of concept investigation in which the performance of a slug flow reactor is investigated by using a transaminase based reaction producing methylbenzylamine (MBA) an active pharmaceutical ingredient (API).

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Kontakt

Virksomhed/organisation

DTU Kemiteknik

Navn

Ulrich Krühne

Stilling

Lektor

Mail

ulkr@kt.dtu.dk

Vejleder-info

Kandidatuddannelsen i Kemisk og Biokemisk Teknologi

Vejleder

Ulrich Krühne

ECTS-point

30 - 35

Type

Bachelorprojekt, Kandidatspeciale

OM DTU

DTU er et teknisk eliteuniversitet med international rækkevidde og standard. Vores mission er at udvikle og nyttiggøre naturvidenskab og teknisk videnskab til gavn for samfundet. 10.000 studerende uddanner sig her til fremtiden, og 5.700 medarbejdere har hver dag fokus på uddannelse, forskning, myndighedsrådgivning og innovation, som bidrager til øget vækst og velfærd.

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Anker Engelunds Vej 1
Bygning 101A
2800 Kgs. Lyngby


45 25 25 25

dtu@dtu.dk

CVR-nr. 30 06 09 46

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