Projekt

Nanofluidic arrays of single molecules and particles

Udbyder

Vejleder

Sted

København og omegn

Nanofluidics is a technology that enables to array and manipulate single molecules and supramolecular assemblies like lipid vesicles. In experiments, nanofluidics is combined with fluorescence microscopy. Recently we worked with genomic DNA, as a physical object [1,2] but also as the carrier for the genetic code [3]. Working with experimental nanofluidics gives the opportunity to investigate biophysics and/or pursue technological goals with applications in life science.

This project is an interdisciplinary project based on experimental work with nanofluidics devices and single molecule fluorescence microscopy. In particular, you will start doing simple experiments to get trained in microscopy and nanofluidics using existing nanofluidics devices. From there, the project is very open and you will define your experimental work and hypothesis with your supervisor. You will be supervised in working with single molecule fluorescence microscopy, micro and nanofluidics experimental work and data analysis based on image analysis.

http://www.nanotech.dtu.dk/Research-mega/Forskningsgrupper/Nanofluidics-Bio

References:
1. Pedersen, J. N., Marie, R., Kristensen, A., & Flyvbjerg, H. (2016). How to determine local stretching and tension in a flow-stretched DNA molecule. Physical Review E, 93(4), 042405. doi:10.1103/PhysRevE.93.042405

2. Pedersen, J. N., Lüscher, C. J., Marie, R., Thamdrup, L. H., Kristensen, A., & Flyvbjerg, H. (2014). Thermophoretic forces on DNA measured with a single-molecule spring balance. Physical Review Letters, 113(26), 268301

3. Marie, R., Pedersen, J. N., L. V. Bauer, D., Rasmussen, K. H., Yusuf, M., Volpi, E., … U. Mirb, K. (2013). Integrated view of genome structure and sequence of a single DNA molecule in a nanofluidic device. National Academy of Sciences. Proceedings, 110(13), 4893–4898    

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Kontakt

Virksomhed/organisation

DTU Sundhedsteknologi

Navn

Rodolphe Marie

Stilling

Gruppeleder, Lektor

Mail

rcwm@dtu.dk

Vejleder-info

Bachelor i Fysik og Nanoteknologi

Vejleder

Rodolphe Marie

ECTS-point

5 - 35

Type

Bachelorprojekt, Fagprojekt, Kandidatspeciale, Specialkursus

Bachelor i General Engineering

Vejleder

Rodolphe Marie

ECTS-point

5 - 35

Type

Bachelorprojekt, Fagprojekt, Kandidatspeciale, Specialkursus

Bachelor i Medicin og Teknologi

Vejleder

Rodolphe Marie

ECTS-point

5 - 35

Type

Bachelorprojekt, Fagprojekt, Kandidatspeciale, Specialkursus

Bachelor i Teknisk Biomedicin

Vejleder

Rodolphe Marie

ECTS-point

5 - 35

Type

Bachelorprojekt, Fagprojekt, Kandidatspeciale, Specialkursus

Kandidatuddannelsen i Fysik og Nanoteknologi

Vejleder

Rodolphe Marie

ECTS-point

5 - 35

Type

Bachelorprojekt, Fagprojekt, Kandidatspeciale, Specialkursus

Kandidatuddannelsen i Medicin og Teknologi

Vejleder

Rodolphe Marie

ECTS-point

5 - 35

Type

Bachelorprojekt, Fagprojekt, Kandidatspeciale, Specialkursus

Kandidatuddannelsen i Bioteknologi

Vejleder

Rodolphe Marie

ECTS-point

5 - 35

Type

Bachelorprojekt, Fagprojekt, Kandidatspeciale, Specialkursus

OM DTU

DTU er et teknisk eliteuniversitet med international rækkevidde og standard. Vores mission er at udvikle og nyttiggøre naturvidenskab og teknisk videnskab til gavn for samfundet. 10.000 studerende uddanner sig her til fremtiden, og 5.700 medarbejdere har hver dag fokus på uddannelse, forskning, myndighedsrådgivning og innovation, som bidrager til øget vækst og velfærd.

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Anker Engelunds Vej 1
Bygning 101A
2800 Kgs. Lyngby


45 25 25 25

dtu@dtu.dk

CVR-nr. 30 06 09 46

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