Imaging of chemical microenvironment of pathogenic biofilms




Greater Copenhagen area

Biofilms are much more tolerant to antibiotics than planktonic bacteria due to factors such as physical
protection and slow growth-rates caused by diffusion limitation of metabolic substrates due to high
bacterial- and immune cell activity.

A more detailed understanding of the chemical microenvironment, and thus resource availability, around pathogenic biofilms could lead to faster and easier diagnostics and provide tools for the development of novel treatment strategies.

In this project, the student will work on developing methods for high resolution imaging of chemical species using indicator dyes of e.g. pH and O2 to investigate heterogeneities in chemical landscapes on a microscale to elucidate interactions between chemical microenvironment and growth rates of pathogenic bacteria.

Required qualifications:
The student should be familiar with basic laboratory techniques, such as pipetting and reagent preparation.

In addition, the student should be able to work independently and be intrigued by technical challenges and method development.

Allowed no of students: 1

In collaboration with

University of Copenhagen

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Company / Organization

DTU Sundhedsteknologi


Thomas Sams


Sektionsleder for Biomedical Engineering, Lektor, PhD


Supervisor info

MSc in Biomedical Engineering


Thomas Sams


MSc thesis

Technical University of Denmark

For almost two centuries DTU, Technical University of Denmark, has been dedicated to fulfilling the vision of H.C. Ørsted – the father of electromagnetism – who founded the university in 1829 to develop and create value using the natural sciences and the technical sciences to benefit society.

Today, DTU is ranked as one of the foremost technical universities in Europe, continues to set new records in the number of publications, and persistently increases and develops our partnerships with industry, and assignments accomplished by DTU’s public sector consultancy.

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CVR-nr. 30 06 09 46

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