Project

The use of lactic acid bacteria for oral delivery of peptide drugs

Publisher

Supervisor

Location

Greater Copenhagen area

Purpose of the idea:

This project will elucidate an alternative road to oral peptide therapy exemplified with hormones relevant in human medicine delivered by lactic acid bacteria (LAB).

 

Hypothesis:

We have developed LAB peptide delivery platform which is highly efficient compared with current bacterial drug delivery vectors based on LAB. The student will work with different strains of LAB including our platform strain.

The project will include a comparison of yields between different strains as well as engineering of these for optimised production of peptides with relevant medical purposes for treatment of different metabolic and inflammatory diseases. The project is seeking a student with a strong interest for laboratory work as well as an interest in biomedical science and microbiology.

 

We are collaborating with other groups at DTU Food and we have the possibility to conduct animal experiments with promising bacterial strains.

 

Planned work:

    I.     Initial candidates are cloned into the bacterial strain by the use of Gibson cloning vector including different tags for various purposes.

   II.     Characterize both wild type and mutant clones of L. Lactis with respect to protein secretion yield and activity in vitro.

 III.     Analyse how the strains and peptides tolerate the environment in the intestines (by setting up ex vivo fermentation in a gastric micro environment).

 IV.     Analyse to what extent efficient protein production yield and fast growth can be obtained under this condition.

 

For more information contact:

 

DTU FOOD

Forskningsgruppen for Mikrobiel Bioteknologi og Bioraffinering

Danmarks Tekniske Universitet

Claus Heiner Bang-Berthelsen 

Tlf: 29866900

E-mail: claban@food.dtu.dk

  

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Contact

Company / Organization

DTU Fødevareinstituttet

Name

Claus Heiner Bang-Berthelsen

Position

Seniorforsker

Mail

claban@food.dtu.dk

Supervisor info

BSc in Biomedical Engineering

Supervisor

Claus Heiner Bang-Berthelsen

ECTS credits

10 - 40

Type

Final project, BSc project, MSc thesis, Special course

BSc in Biotechnology

Supervisor

Claus Heiner Bang-Berthelsen

ECTS credits

10 - 40

Type

Final project, BSc project, MSc thesis, Special course

BSc in Chemistry and Technology

Supervisor

Claus Heiner Bang-Berthelsen

ECTS credits

10 - 40

Type

Final project, BSc project, MSc thesis, Special course

MSc in Biomedical Engineering

Supervisor

Claus Heiner Bang-Berthelsen

ECTS credits

10 - 40

Type

Final project, BSc project, MSc thesis, Special course

MSc in Biotechnology

Supervisor

Claus Heiner Bang-Berthelsen

ECTS credits

10 - 40

Type

Final project, BSc project, MSc thesis, Special course

MSc in Chemical and Biochemical Engineering

Supervisor

Claus Heiner Bang-Berthelsen

ECTS credits

10 - 40

Type

Final project, BSc project, MSc thesis, Special course

MSc in Food Technology

Supervisor

Claus Heiner Bang-Berthelsen

ECTS credits

10 - 40

Type

Final project, BSc project, MSc thesis, Special course

MSc in Bioinformatics and Systems Biology

Supervisor

Claus Heiner Bang-Berthelsen

ECTS credits

10 - 40

Type

Final project, BSc project, MSc thesis, Special course

Technical University of Denmark

For almost two centuries DTU, Technical University of Denmark, has been dedicated to fulfilling the vision of H.C. Ørsted – the father of electromagnetism – who founded the university in 1829 to develop and create value using the natural sciences and the technical sciences to benefit society.


Today, DTU is ranked as one of the foremost technical universities in Europe, continues to set new records in the number of publications, and persistently increases and develops our partnerships with industry, and assignments accomplished by DTU’s public sector consultancy.

Find us here

Anker Engelunds Vej 1
Bygning 101A
2800 Kgs. Lyngby

Denmark



Tlf. (+45) 45 25 25 25

CVR-nr. 30 06 09 46

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