Project

Computational fluid dynamic (CFD) simulation of enzymatic hydrolysis of keratin waste material at high solids loading in a scraped surface bioreactor

Publisher

Supervisor

Location

Greater Copenhagen area

The enzymatic hydrolysis of keratin waste biomass is a conversion process that employs microbial keratinases to decompose keratin-rich substrates. The soluble proteins, peptides and free amino acids released during the process are a viable alternative protein source to fish meal for aquaculture. It is desirable to perform the keratin degradation process at high solids loadings in order to maximize product titer and reduce process water, energy usage, and reactor size. However, high solids slurries are highly viscous by nature, and their hydrolysis poses a serious challenge in obtaining effective mixing and efficient heat transfer inside the bioreactor. Consequently, conventional stirred tank reactors with typical impeller configurations are not practical for this application because of high stirring speeds needed to mix the slurry and keep the solids suspended. Gravitational or free-fall horizontal mixing systems such as scraped surface slurry bioreactors have proven to offer several advantages over typical stirred tank reactors. The horizontal scraping action of the impellers in a free fall principle reactor requires very low rotation rates and, hence, much less power while preventing particle settling and local accumulation of reaction products, as well as ensuring better enzyme distribution. Moreover, the scraping action of the blades maintains a clear reactor surface and, thereby, improves heat transfer.

 

In this project, the student will develop a computational fluid dynamic (CFD) model which, in turn, will be used to gain insight into the mixing behavior of the particulate system within a horizontal scraped surface slurry reactor. In particular, while designing the reactor, knowledge of the local flow patterns will be fundamental in achieving more uniform mixing and therefore improved heat and mass transfer. The computational multiphase flow model developed will be used, in a following project, as the starting point for the construction of a laboratory unit.

 

We are looking for a highly motivated MSc. student in Biochemical engineering with the following skills:

- General knowledge in CFD or keen on learning CFD

- Good knowledge of transport phenomena

- Knowledge of rheological behavior of non-Newtonian fluids will be considered as a plus


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Contact

Company / Organization

DTU Kemiteknik

Name

Ulrich Krühne

Position

Lektor

Mail

ulkr@kt.dtu.dk

Supervisor info

MSc Eng in Applied Chemistry

Supervisor

Ulrich Krühne

Co-supervisors

Krist V. Gernaey, Ines Pereira Rosinha Grundtvig, Francesco Cristino Falco

ECTS credits

30 - 35

Type

MSc thesis

MSc in Chemical and Biochemical Engineering

Supervisor

Ulrich Krühne

Co-supervisors

Krist V. Gernaey, Ines Pereira Rosinha Grundtvig, Francesco Cristino Falco

ECTS credits

30 - 35

Type

MSc thesis

MSc in Mathematical Modelling and Computation

Supervisor

Ulrich Krühne

Co-supervisors

Krist V. Gernaey, Ines Pereira Rosinha Grundtvig, Francesco Cristino Falco

ECTS credits

30 - 35

Type

MSc thesis

Technical University of Denmark

For almost two centuries DTU, Technical University of Denmark, has been dedicated to fulfilling the vision of H.C. Ørsted – the father of electromagnetism – who founded the university in 1829 to develop and create value using the natural sciences and the technical sciences to benefit society.


Today, DTU is ranked as one of the foremost technical universities in Europe, continues to set new records in the number of publications, and persistently increases and develops our partnerships with industry, and assignments accomplished by DTU’s public sector consultancy.

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