Project

In vitro electrochemical monitoring of allergic reactions

Publisher

Supervisor

Location

Greater Copenhagen area

The prevalence of allergic diseases is increasing worldwide, especially in low and middle income countries. Allergic diseases comprehend life-threatening anaphylaxis, food allergies, certain forms of asthma, rhinitis, conjunctivitis, eczema, angioedema, urticarial, eosinophilic disorders, drug and insect allergies. The World Allergy Organization estimated that 20-30% of the world population suffered from some form of allergic disease in 2003, with the greatest burden for children and young men. One tenth of the world population suffers for drug allergies and 400 million for rhinitis and about 250 million are allergic to some kind of food. 

Although a lot of research has been conducted to investigate the mechanisms behind allergic reactions there is still a lack of knowledge on several fundamental phenomena related to allergy. Here, we propose the development of an in vitro model which could provide real-time electrochemical monitoring of degranulation of mast cells triggered by allergic reactions. Carbon microelectrodes will be fabricated in the Danchip cleanroom. Mast cells will be cultured on the electrodes and the release of histamine upon mast cell activation will be studied. The long-term vision is to develop a new type of allergy test. The project is conducted as a collaboration between DTU Nanotech and the Allergy Clinic at Gentofte Hospital.
Search in postings
Contact

Company / Organization

DTU Nanolab

Name

Stephan Sylvest Keller

Position

Lektor

Mail

suke@dtu.dk

Supervisor info

BSc in Biomedical Engineering

Supervisor

Stephan Sylvest Keller

ECTS credits

25 - 35

Type

MSc thesis

BSc in Biotechnology

Supervisor

Stephan Sylvest Keller

ECTS credits

25 - 35

Type

MSc thesis

BSc in Human Life Science Engineering

Supervisor

Stephan Sylvest Keller

ECTS credits

25 - 35

Type

MSc thesis

MSc in Biomedical Engineering

Supervisor

Stephan Sylvest Keller

ECTS credits

25 - 35

Type

MSc thesis

MSc in Biotechnology

Supervisor

Stephan Sylvest Keller

ECTS credits

25 - 35

Type

MSc thesis

MSc in Pharmaceutical Design and Engineering

Supervisor

Stephan Sylvest Keller

ECTS credits

25 - 35

Type

MSc thesis

Technical University of Denmark

For almost two centuries DTU, Technical University of Denmark, has been dedicated to fulfilling the vision of H.C. Ørsted – the father of electromagnetism – who founded the university in 1829 to develop and create value using the natural sciences and the technical sciences to benefit society.


Today, DTU is ranked as one of the foremost technical universities in Europe, continues to set new records in the number of publications, and persistently increases and develops our partnerships with industry, and assignments accomplished by DTU’s public sector consultancy.

Find us here

Anker Engelunds Vej 1
Bygning 101A
2800 Kgs. Lyngby

Denmark



Tlf. (+45) 45 25 25 25

CVR-nr. 30 06 09 46

All vacant positions
 

loading..