In the Nanofluidics and Bioimaging group, we use micro and nanofluidics to facilitate the imaging of biological particles. We have previously worked with single cells , chromosomes  and DNA molecules [3,4]. Each new idea starts with the design and fabrication of a fluidic device follow by testing and application, often involving fluorescence microscopy.
Fabrication methods could be micro/nano fabrication in cleanroom, micro-milling of a metal master for injection moulding, 3D printing.
In one project, we want to make a microfluidic flow cells for imaging cells using advanced super-resolution microscopy. With access to a new type of optical super-resolution microscope, you can be the first one to design and fabricate a flow cell for that imaging technique with applications in biology and biophysics.
In another project, we want to make a device for creating solute and solvent gradients for the imaging of nanoparticles. This has application in biophysics.
You will design a device, perform simulations, fabricate your device and test it. You will be supervised for working with microfluidic device design, cleanroom fabrication, fluorescence microscopy and practical microfluidic work. If you already have worked with cleanroom microfabrication, this is a great way to kick start your project. Contact me to know more!
1.Marie, R., Pødenphant, M., Koprowska, K., Baerlocher, L., Vulders, R. C. M., Wilding, J., … Mir, K. U. (2018). Sequencing of human genomes extracted from single cancer cells isolated in a valveless microfluidic device. Lab on a Chip, 18(13), 1891–1902. https://doi.org/10.1039/c8lc00169c
2. Rasmussen, K. H., Marie, R., Moresco, J. L., Svendsen, W. E., Kristensen, A., & Mir, K. U. (2011). A device for extraction, manipulation and stretching of DNA from single human chromosomes. Lab on a Chip, 11(8), 1431–1433. https://doi.org/10.1039/c0lc00603c
3. Marie, R., Pedersen, J. N., Mir, K. U., Bilenberg, B., & Kristensen, A. (2018). Concentrating and labeling genomic DNA in a nanofluidic array. Nanoscale, 10(3), 1376–1382. https://doi.org/10.1039/c7nr06016e
4. Marie, R., Pedersen, J. N., Bærlocher, L., Koprowska, K., Pødenphant, M., Sabatel, C., … Mir, K. U. (2018). Single-molecule DNA-mapping and whole-genome sequencing of individual cells. Proceedings of the National Academy of Sciences of the United States of America, 201804194. https://doi.org/10.1073/pnas.1804194115