Project

Detection of early biomarkers for Alzheimers disease

Publisher

Supervisor

Location

Greater Copenhagen area

Over-aging and today’s lifestyle bring along an increase in both prevalence and incidence of certain diseases such as dementia.

The majority of dementia cases is caused by Alzheimer's disease (AD), a progressive fatal brain disorder that entails severe social and economic consequences.

At this time, there is no cure for AD and its cause and progression are not completely understood. A definite diagnosis can only be made post mortem. Clinical studies suggest biomedical (neural) signals as diagnostic supplement.

Advanced digital biomedical signal processing are necessary to identify biomarkers that improve early diagnostics and, as consequence, clinical studies and the treatment of AD.

Objective:

Main objective is the study of neural and other Biomedical signals of AD patients, and the application of methods for automated feature extraction. These features will be used for classification of different stages of AD with the aim of providing valuable diagnostic information for the Medical doctors.

In the project one will analyze patterns in and the relation between biomedical signals such as EEG, EOG and ECG, in order to identify healthy subjects and subjects with a neurodegenerative disease. Since these biomedical signals are very sensitive and prone to artefacts, careful automated preprocessing procedures have to applied in close correspondence with the expertise of medical doctors. Patterns in and the relation between the preprocessed features will then be quantified and a set of features will be developed. Based on these features, an automated classification of healthy subjects and subjects in different disease states should be achieved with highest possible accuracy. The project is associated with research groups from DTU and Rigshospitalet Glostrup.

In collaboration with

Professor, overlæge dr.med. Poul Jennum, Rigshospitalet, Glostrup

Requirements

Signal processing, experience in Matlab and profound mathematical skills.

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Contact

Company / Organization

DTU Sundhedsteknologi

Name

Helge Bjarup Dissing Sørensen

Position

Gruppeleder, Lektor MSK, Ph.D.

Mail

hbds@dtu.dk

Supervisor info

BSc in Electrical Engineering

Supervisor

Helge Bjarup Dissing Sørensen

Type

BSc project, MSc thesis

BSc in Biomedical Engineering

Supervisor

Helge Bjarup Dissing Sørensen

Type

BSc project, MSc thesis

MSc in Electrical Engineering

Supervisor

Helge Bjarup Dissing Sørensen

Type

BSc project, MSc thesis

MSc in Biomedical Engineering

Supervisor

Helge Bjarup Dissing Sørensen

Type

BSc project, MSc thesis

Technical University of Denmark

For almost two centuries DTU, Technical University of Denmark, has been dedicated to fulfilling the vision of H.C. Ørsted – the father of electromagnetism – who founded the university in 1829 to develop and create value using the natural sciences and the technical sciences to benefit society.


Today, DTU is ranked as one of the foremost technical universities in Europe, continues to set new records in the number of publications, and persistently increases and develops our partnerships with industry, and assignments accomplished by DTU’s public sector consultancy.

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