computer modelling and simulation of freeze drying processes at Novo Nordisk




Greater Copenhagen area

Lyophilisation, or freeze drying, removes water by sublimation at low temperature and pressure and is widely used in the biopharmaceutical industry to stabilise and maintain the biological activity of active pharmaceutical protein or peptide molecules.

The freeze drying process contains three steps including freezing, followed by primary and secondary drying as shown in Figure 3. To better understand the freezing step and the behaviour of the aqueous formulation containing the active ingredients, a mathematical model – as a simplified representation of the freezing process – would be highly valuable.

The aim of this project is to develop a deterministic model of the super cooling and freezing behaviour of the aqueous formulation at different cooling rates based on temperature measurement data obtained in a full scale freeze drier system at Novo Nordisk.

In collaboration with

Novo Nordisk A/S


Strong background in mathematical modellin in chemical engineering

Download Materials

Search in postings

Company / Organization

DTU Kemiteknik


Ulrich Krühne




Supervisor info

MSc in Chemical and Biochemical Engineering


Ulrich Krühne

ECTS credits

30 - 35


BSc project, MSc thesis

Must be completed


Technical University of Denmark

For almost two centuries DTU, Technical University of Denmark, has been dedicated to fulfilling the vision of H.C. Ørsted – the father of electromagnetism – who founded the university in 1829 to develop and create value using the natural sciences and the technical sciences to benefit society.

Today, DTU is ranked as one of the foremost technical universities in Europe, continues to set new records in the number of publications, and persistently increases and develops our partnerships with industry, and assignments accomplished by DTU’s public sector consultancy.

Find us here

Anker Engelunds Vej 1
Bygning 101A
2800 Kgs. Lyngby


Tlf. (+45) 45 25 25 25

CVR-nr. 30 06 09 46

All vacant positions