or freeze drying, removes water by sublimation at low temperature and pressure
and is widely used in the biopharmaceutical industry to stabilise and maintain
the biological activity of active pharmaceutical protein or peptide molecules.
drying process contains three steps including freezing, followed by primary and
secondary drying as shown in Figure 3. To
better understand the freezing step and the behaviour of the aqueous
formulation containing the active ingredients, a mathematical model – as a
simplified representation of the freezing process – would be highly valuable.
The aim of this project is to develop a deterministic
model of the super cooling and freezing behaviour of the aqueous formulation at
different cooling rates based on temperature measurement data obtained in a
full scale freeze drier system at Novo Nordisk.
In collaboration withNovo Nordisk A/S
Strong background in mathematical modellin in chemical engineering