Slug flow µ-reactors for two-liquid phase biocatalysis




Greater Copenhagen area

In biocatalytic reaction it is often favorable to have reaction conditions, where two different fluid dynamic phases are in contact with each other. This might for instance be a water-based phase holding the water soluble fractions of reaction components like enzymes, while another phase is insoluble in water and containing the other substrates of the reaction. _x000D_ _x000D_ Very often a so called slug flow reactor is used in minaturized approaches, where the different phases are introduced with help of continious flowrates resulting in a segmented flow of different phases. _x000D_ Comlex flow fields are obtained with intensive secondary flows, resulting in good mixing (see for example Taha and Cui, 2006, CFD modelling of slug flow inside square capillaries, Chemical Engineering Science, 61, 665-675)._x000D_ _x000D_ Using minaturized slug flow reactors for biocatalytic reactions gain more and more importance since it is possible to separate water based active components from substrates dissolved in more aggressive environments, which would inhibit or destroy the acitve sites of the biocatalysts. Furthermore the different phases can also be used to apply liquid liquid extraction from products and to influence in this way the thermodynamic equilibrium._x000D_ _x000D_ The proposed project wil perform a proof of concept investigation in which the performance of a slug flow reactor is investigated by using a transaminase based reaction producing methylbenzylamine (MBA) an active pharmaceutical ingredient (API).

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Company / Organization

DTU Kemiteknik


Ulrich Krühne




Supervisor info

MSc in Chemical and Biochemical Engineering


Ulrich Krühne

ECTS credits

30 - 35


BSc project, MSc thesis

Technical University of Denmark

For almost two centuries DTU, Technical University of Denmark, has been dedicated to fulfilling the vision of H.C. Ørsted – the father of electromagnetism – who founded the university in 1829 to develop and create value using the natural sciences and the technical sciences to benefit society.

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