Project

Structure-activity relationships of Neuronal Nicotinic Acetylcholine Receptors

Publisher

Supervisor

Location

Greater Copenhagen area

The focus of the project is to study the structure-activity relationships of Neuronal Nicotinic Acetylcholine Receptors (nAChRs). These receptors are ligand-gated ion channels, assembled by α- and β-subunits. The heteromeric α4β2- and the homomeric α7-receptors are the most prevalent subtypes in the mammalian brain. The involvement of nAChRs in a number of different decease states of the CNS (such as ADHD, Alzheimer’s and Parkinson’s disease, substance abuse and pain) has made this class of receptors a popular target for drug discovery.

The objective is to screen for potential ligands that can modulate using computational (in-silico) tools.
This project is performed in collaboration with the
Department of Drug Design and Pharmacology at the University of Copenhagen that will synthesize and test the different ligands in order to investigate their potential for modulating nAChR's activity.

In collaboration with

Jesper Langgaard Kristensen (jesper.kristensen@sund.ku.dk) (University of Copenhagen)

Requirements

Knowledge in computational biology

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Technical University of Denmark

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