Project

Immune cell migration in Multiple Sclerosis

Publisher

Supervisor

Location

Greater Copenhagen area

Understanding the migration of immune cells is paramount in a long range of pathological situations. Mapping of cell migration can be done longitudinally using non-invasive imaging of tagged cells.

The main focus of this project is to map the migration pattern of macrophages and T-cell subtypes in CNS inflammation in MS mice. This will be done with the use of Magnetic Resonance Imaging (MRI) using an exogenous contrast agent such as super-paramagnetic iodine oxide. SPIO.

Correlation of immune cell migration over time to the hallmarks of MS, demyelination and neural loss, as well as clinical disease, will make it possible to elucidate the impact of specific immune cell populations, with high detail and accuracy.

The experiment’s running at NMR center using the Bruker BioSpec 9.4 T MR small animal scanner. The candidate student will work with already optimized MR imaging protocols and will be involved in standardization and system calibration that are crucial in quantitative methods. Understanding the connection between the MR parameters and the biology is crucial, therefore the candidate will work in a highly interdisciplinary environment and will have the opportunity to collaborate with other researchers at the University of Copenhagen and BRIC.

Allowed no. of students: 1-2

In collaboration with

Henrik El Ali, KU

Requirements

Physics

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Contact

Company / Organization

DTU Sundhedsteknologi

Name

Thomas Sams

Position

Sektionsleder for Biomedical Engineering, Lektor, PhD

Mail

tsams@dtu.dk

Supervisor info

BSc in Biomedical Engineering

Supervisor

Thomas Sams

Type

BSc project, MSc thesis

MSc in Biomedical Engineering

Supervisor

Thomas Sams

Type

BSc project, MSc thesis

Technical University of Denmark

For almost two centuries DTU, Technical University of Denmark, has been dedicated to fulfilling the vision of H.C. Ørsted – the father of electromagnetism – who founded the university in 1829 to develop and create value using the natural sciences and the technical sciences to benefit society.


Today, DTU is ranked as one of the foremost technical universities in Europe, continues to set new records in the number of publications, and persistently increases and develops our partnerships with industry, and assignments accomplished by DTU’s public sector consultancy.

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Denmark



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CVR-nr. 30 06 09 46

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