The purpose of this project is to characterize underlying mechanisms of S. aureus
interaction with members of the microbiome, and identify novel probiotics and/or antibiotics.
Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) can cause serious infectious diseases and even death. Recent research suggests that individuals can carry beneficial bacteria that inhibit S. aureus. You will employ cutting-edge genomics, microbial ecology, and molecular biology to identify and characterize the beneficial microorganisms and their interactions with MRSA.
MRSA-infections account for a significant economic burden to the Danish and international healthcare systems, and no successful therapeutic solution exists to reduce MRSA in pigs and humans. In this project you will characterize the host-associated microbiome. Potential beneficial microorganisms that are being identified could be developed as novel probiotics or may turn out to produce novel antimicrobials that could be used to prevent MRSA-colonization or treat infections.
You will be part of a team that includes clinicians, veterinarians, molecular biologists and bioinformaticians. Techniques can include DNA extraction, PCR, creating metagenomic libraries, Next-generation sequencing (incl. Nanopore sequencing), classical microbiological techniques, DNA sequence analyses, and other.
Overall, the main research areas of our group are: the microbiome, genomics, infectious diseases, novel antimicrobials, antibiotic resistance, microbial ecology, microbial interactions, evolution, microbiology, molecular biology, single-cell analysis, epidemiology and global surveillance.
For further information, contact us.